The simgi® (Dynamic Gastrointestinal Simulator) is a unique infrastructure in Spain, located in the Institute of Food Science Research (CIAL), and aims to simulate the human gastrointestinal tract through the evaluation of gastrointestinal digestion processes and colonic fermentation of food and / or food ingredients.
The simgi® is a computer-controlled system that comprises several compartments, including stomach, small
intestine and colon (ascending, transverse and descending).
The stomach is composed of two flexible walls cover by a methacrylate jacket where water is pumped allowing maintenance of a constant temperature and mixing of the stomach contents through peristaltic movements. The system allows varying the pH set point and the time for emptying it into the small intestine.
The small intestine is a continuously stirred reactor where the gastric contents are mixed with intestinal secretions under anaerobic conditions and controlled pH.
The colon consists of three continuously stirred reactors (ascending, transverse and descending colon), operating under anaerobic conditions and controlled pH. The colon hosts a large population of human fecal microbiota.
The simgi® displays collecting points in each of the compartments to carry out the biochemical and microbiological analysis. In addition to the continuous operation, each compartment (stomach, small intestine, and colon) is operable individually.